EZ Gel PRF has recently gained popularity as an alternative PRP treatment, but it raises significant safety and regulatory concerns. Unlike FDA-cleared PRP systems like EmCyte, EZ Gel is only classified as a “Class I” blood collection device, not approved for PRP preparation. Additionally, the practice of heating PRP, as done in the EZ Gel process, is against FDA guidelines and could pose risks to patients. This blog explores the importance of FDA clearance and why practitioners should exercise caution when considering non-approved PRP devices like EZ Gel.